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and diphenylene iodonium, an inhibitor of NOX, in attenuating ROS-induced apoptosis

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It has been reported that TET2 catalyzes the demethylation of 5-methylcytosine (5-mC) by oxidizing 5 mC to 5-hmC, associated with slow-cycling cancer cells.27, 28, 29 Puig and colleagues found that TET2 is required for the survival and drug chemoresistance of slow-cycling cancer cells in multiple tumor types, including melanoma, glioblastoma and colorectal cancer

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